Mac Jones steps in for Brock Purdy as SF navigates a patchwork line, and fantasy managers will chase efficiency from SF’s skill players with a thinner supporting cast. Seattle’s run-first approach squarely tests Pittsburgh’s aging front, a game that could lift or sink value across the Seahawks backfield and JSN.

The Week 2 slate features Eagles-Chiefs, with lofty ceilings on both sides, plus Texans-Buccaneers and Bears-Lions as value-rich chances for breakout games. Hail Marys crown the picks, notably Jaguars over Cincinnati and Minnesota over Atlanta for bold Week 2 outcomes.

Brissett's readiness debate highlights a fantasy risk: a raw quarterback with limited live reps and four OC changes won't unlock production without system stability.

Patience matters; avoid chasing the shine. Monitor reps, scheme fit, run-game support, and coaching cadence before trusting him as a weekly starter in shallow formats.